Abstract:

Objective To analyze optical coherence tomography angiography (OCTA) vessel density of superficial retinal vascular networks and choroidal capillary networks in affected eyes and non-affected eyes of central serous chorioretinopathy (CSC) patients and to explore the pathogenesis of CSC. Design Retrospective case series. Participants 27 patients with CSC and 27 normal people at Beijing Tongren Eye Center from November 2015 to March 2016. Methods All patients underwent OCTA using the RTVue XR Avanti device (Optovue Inc, Fremont, CA) which performed with 3 mm×3 mm Angio Retina mode. The vessel density of superficial retinal vascular networks could be auto-achieved by the OCTA software and the vessel density of choriocapillaris layer could be manually measured in 3 mm and 1mm regions. Main Outcome Measures The OCTA vessel density of superficial retinal vascular networks and choriocapillaris layer. Results On 3 mm×3 mm scans, the mean superficial retinal vessel densities of the whole area were 50.517±3.743 in affected eyes of CSC; and 52.577±3.803 (P=0.042) in non-affected eyes of CSC as well as 48.114± 3.257 (P=0.000) in healthy eyes. The mean choroid capillary vessel densities of the whole area were 56.673±5.750 in affected eyes of CSC; and 60.905±3.174 (P=0.009) in non-affected eyes of CSC as well as 61.361±1.839 (P=0.002) in healthy eyes. Conclusion The superficial retinal vessel density in affected eyes and non-affected fellow eyes of CSC was significantly higher compared to healthy eyes, however, choroid capillary vessel density in affected eyes of CSC was lower than healthy eyes. This might be relevant to central nervous system regulation and choroidal hyperperfusion in CSC. (Ophthalmol CHN, 2018, 27: 58-62)

Key words: central serous chorioretinopathy, optical coherence tomography angiography, vessel density